|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Migraine Disorders
|
0.120 |
GeneticVariation
|
group |
GWASDB |
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
|
23793025 |
2013 |
|
Camurati-Engelmann Syndrome
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease.
|
11062463 |
2000 |
|
Camurati-Engelmann Syndrome
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Camurati-Engelmann Syndrome
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Cystic Fibrosis
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Camurati-Engelmann Syndrome
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Osteoclast formation was enhanced approximately 5-fold (P < 0.001) and bone resorption approximately 10-fold (P < 0.001) in CED patients, and the increase in osteoclast formation was inhibited by soluble TGFbeta type II receptor.
|
12843182 |
2003 |
|
Camurati-Engelmann Syndrome
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Our data indicate that the mutations in the signal peptide and latency-associated peptide facilitate TGF-beta1 signaling, thus causing Camurati-Engelmann disease.
|
12493741 |
2003 |
|
Camurati-Engelmann Syndrome
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.
|
10973241 |
2000 |
|
Camurati-Engelmann Syndrome
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
TGFB1 mutations in four new families with Camurati-Engelmann disease: confirmation of independently arising LAP-domain-specific mutations.
|
15103729 |
2004 |
|
Camurati-Engelmann Syndrome
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease.
|
11062463 |
2000 |
|
INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy.
|
29483653 |
2018 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
RGD |
The levels of TGF-beta1 mRNA and collagen type III in cigarette smoke treated group (0.42 +/- 0.04, 25.8 +/- 2.3) were higher than those in the asthmatic group (0.39 +/- 0.04, 22.9 +/- 3.1) and in the control group (0.26 +/- 0.04, 16.3 +/- 2.3).
|
18366906 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
RGD |
The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-β1 in the myocardium of rats with diabetes.
|
24613393 |
2014 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
RGD |
Silencing CD36 gene expression results in the inhibition of latent-TGF-beta1 activation and suppression of silica-induced lung fibrosis in the rat.
|
19439069 |
2009 |
|
Pulmonary Fibrosis
|
0.700 |
Therapeutic
|
disease |
RGD |
The results showed that BLM resulted in severe PF and diffuse lung inflammation, together with significant elevation of inflammatory factors and a marked increase in expression of angiotensin II (ANG II) and transforming growth factor-beta 1 (TGF-β1).
|
26822530 |
2016 |
|
Diabetic Nephropathy
|
0.600 |
Therapeutic
|
disease |
RGD |
Antioxidant and pro-oxidant effects of oil palm (Elaeis guineensis) leaves extract in experimental diabetic nephropathy: a duration-dependent outcome.
|
24074026 |
2013 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
RGD |
Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle.
|
26923362 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
These results suggested that ERK 1/2 could be activated by phosphorylation with over-expression of TGF-beta1 in the endothelium and in VSMC of aorta and renal arterioles from SHR, which might play an important role in VSMC proliferation under hypertension.
|
17364610 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
At similar levels of systemic hypertension, Dahl salt-sensitive but not spontaneously hypertensive rats (SHR) develop glomerular hypertension, which is accompanied by upregulation of transforming growth factor beta1 (TGF-beta1), mesangial matrix expansion, and sclerosis.
|
12771048 |
2003 |
|
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
RGD |
Only animals from the 1WIK group developed severe chronic renal failure, glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1) (TGF-beta(1)) gene, which was associated with increased TGF-beta(1) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate.
|
10919844 |
2000 |
|
Lung diseases
|
0.600 |
Biomarker
|
group |
RGD |
Pyrrolidine dithiocarbamate attenuates paraquat-induced lung injury in rats.
|
19639047 |
2009 |
|
Lung diseases
|
0.600 |
Biomarker
|
group |
RGD |
Early administration of propofol protects against endotoxin-induced acute lung injury in rats by inhibiting the TGF-beta1-Smad2 dependent pathway.
|
19941153 |
2010 |
|
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
RGD |
[Expression of secretory leukocyte proteinase inhibitor in the bronchi and lung tissues of chronic obstructive pulmonary disease rat models and the regulatory mechanism by transforming growth factor beta(1)].
|
18269849 |
2007 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Simvastatin ameliorates ventricular remodeling via the TGF‑β1 signaling pathway in rats following myocardial infarction.
|
27121011 |
2016 |